TRAC for ADME-Tox: Products and services

TRAC is ideal for pre-clinical drug studies, as it allows the ADME-Tox profile of a drug to be investigated in many hundreds of samples, without sacrificing the number of genes being analysed. TRAC is also cost-effective and fast, allowing screening to be carried out very efficiently. Using gene expression to assess ADME-Tox response is especially powerful, as indicated in a recent draft report by the FDA, which recommended its suitability over protein-based methods.

We offer a range of pre-validated TRAC panels for ADME-Tox research in a range of model systems, including rat, humans and dogs. You can:

 

Human ADME-Tox library

Over 6 reference genes and many targets to choose from, including:

  • 14 CYP 450 genes, including all FDA-recommended CYP targets
  • Glucuronosyl Transferases
  • Glutathione Transferases
  • ABC Transporters

Dedicated Human ADME-Tox services using our panels of pre-validated ADME-Tox probes:

  • FAST TRAC  – our in house gene expression service
  • TRACPACK-CYP+ mRNA – rapid service for early-stage compound screening measuring CYP gene expression
  • TRACPACK INDUCTION – more in depth compound analysis service for assessing CYP expression and activity profile

Rat ADME-Tox library

More than 120 targets and over 14 reference genes to choose from, including:

  • Markers for hepatotoxicity, necrosis, cholestasis and steatosis
  • Drug metabolism and transport pathways
  • Learn more and see some of the data associated with TRAC rat ADME-Tox probes...

Dog ADME-Tox library

A panel of the most common CYP 450 genes and reference genes for primary hepatocyte induction studies - Learn more

 

What if I want to create my own custom gene panel?

No problem! TRAC can be used to analyze the expression of any gene where the DNA sequence is known 

Contact us for more details

Why use TRAC for ADME-Tox?

  1. TRAC offers many cost, time and technical  advantages over alternative methods such as qPCR and microarrays
  2. Gene expression analysis is recommended by the FDA as the method of choice for measuring CYP pathway activity 
  3. TRAC allows many thousands of samples to be processed quickly and automatically, so that drugs can be screened rapidly and efficiently
  4. Drugs likely to be toxic or ineffective can be identified early, before costly clinical trials have taken place

Many research laboratories have already taken advantage of the TRAC approach for investigating drug absorption, distribution, metabolism, excretion and toxicity. More details can be found by visiting the applications section of our site or by viewing a list of Plexpress and independent scientific research papers that have used TRAC.

In addition, TRAC is offered by several CROs to help research teams push their research forward. Contact us for more information.